Possible roles for miRNAs during embryonic gonad development when you look at the chicken

AMH signal transduction via the TGF-Я signalling path and possible involvement of miRNAs.

AMH binds specifically towards the AMH receptor (AMHR2), which activates either activin receptor 1 (ACVR1), or bone tissue morphogenic receptor 1A (BMPR1A), or 1B (BMPR1B). Activated ACVR1 and BMPR1A transduce AMH signals by activating SMAD signalling proteins (SMAD1, 5 or 8), with the help of ZEB1. BMPR1B competitively antagonises SMAD activation. Continue reading